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Showing 1–11 of 11 results
Advanced filters: Author: Lowell Ling Clear advanced filters
  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103
  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768
  • The authors develop an approach for enhancing the wear resistance and lubricity of metals at elevated temperatures of in oxidative environments, where traditional solid lubricants fail. By engineering surface oxidation in additively manufactured Inconel, they achieve low friction coefficients, between 0.10 and 0.32 at 600-900 °C, through the formation of a spinel-based oxide layer.

    • Zhengyu Zhang
    • Eitan Hershkovitz
    • Wenjun Cai
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12
  • Cheek swabs are widely used in pediatric epigenetic studies, but changes in their cellular composition with age are unclear. Here the authors show that buccal epithelial cells decline with age until adolescence, then stabilize, while variability increases with age, impacting the precision of tools like the PedBE clock in pediatric epigenetics.

    • Sarah M. Merrill
    • Chaini Konwar
    • Michael S. Kobor
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

    • Erola Pairo-Castineira
    • Sara Clohisey
    • J. Kenneth Baillie
    Research
    Nature
    Volume: 591, P: 92-98
  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477
  • Nonvolatile memory devices based on hybrid inorganic/organic nanocomposites have emerged as excellent candidates for promising applications in next-generation electronic and optoelectronic devices because of their advantages of high-mechanical flexibility, simple fabrication and low cost. As shown in the figure, the resistive switching of a nanocomposite sandwiched between two electrodes enables the cross-point where A and B cross to work as a memory cell for data storage. To date, various nanomaterials and device structures have been developed to optimize the memory properties of hybrid nanocomposites.

    • Tae Whan Kim
    • Yang Yang
    • Wei Lek Kwan
    ReviewsOpen Access
    NPG Asia Materials
    Volume: 4, P: e18